Efficacy of Nebulized 3% Hypertonic Saline for the Treatment of Bronchiolitis: A Systematic Review
Sciencevolution v4.2 2025 - 139 - Portada
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Keywords

Efficacy
Saline Solution Hypertonic
Nebulizers
Child
Bronchiolitis

How to Cite

Nogales Astete, J. L. (2025). Efficacy of Nebulized 3% Hypertonic Saline for the Treatment of Bronchiolitis: A Systematic Review. Journal SCIENCEVOLUTION, 4(2), 139–150. https://doi.org/10.61325/ser.v4i2.188

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https://n2t.net/ark:/55066/SER.v4i2.188

Abstract

Bronchiolitis is defined as the first episode of lower respiratory tract infection in patients under 2 years of age. Despite numerous studies, there is still insufficient data to draw firm conclusions regarding its efficacy (or lack thereof). For these reasons, a systematic review was conducted to evaluate the efficacy and safety of 3% nebulized saline solution in patients with acute bronchiolitis. A systematic review was performed following the PRISMA methodology. The search yielded 874 articles; after removing duplicates, screening titles/abstracts for relevance, and assessing content, 10 studies were selected. Several reviewed articles affirmed its effectiveness in reducing symptoms or clinical severity. Analysis of adverse effects confirmed a low occurrence of mild adverse reactions, or even their absence, with no serious adverse effects reported. The reviewed articles reported hospital stays ranging from 3.7 to 4 days and earlier hospital discharges. Despite significantly modifying these variables, it was generally reported that there is insufficient evidence of its effectiveness. It is concluded that it is a safe treatment in pediatric patients with bronchiolitis, associated with minor adverse events, but further studies are needed to confirm its efficacy.

https://doi.org/10.61325/ser.v4i2.188
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