Keywords
Differential diagnosis
Structural neuroimaging
Psychometric tests
Biomarkers
How to Cite
Abstract
The central objective of this literature review is to unravel the structural and functional differences present in cortical dementias in order to provide essential tools for an accurate differential diagnosis. To achieve this, a meticulous selection and analysis of articles from renowned databases such as Pubmed, Scopus, and Google Scholar were undertaken, all of which were filtered based on specific inclusion criteria. From this thorough review, two fundamental findings emerged: firstly, the criticality of specificity and sensitivity in psychometric tests and biomarkers is highlighted. Secondly, the paramount importance of utilizing structural neuroimaging and, furthermore, the combination of different neuroimaging techniques for a differential diagnosis of cortical dementias is emphasized. In summary, given the rising projection of cortical dementias in the population and the multiple factors and comorbidities they present, advanced neuroimaging tools and rigorous tests are vital for achieving an early and proper diagnosis.
References
Barber, R., Ballard, C., McKeith, I. G., Gholkar, A., & O'Brien, J. T. (2000). MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia. Neurology, 54(6), 1304–1309. https://doi.org/10.1212/wnl.54.6.1304.
Barber, R., McKeith, I. G., Ballard, C., Gholkar, A., & O'Brien, J. T. (2001). A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study. Dementia and geriatric cognitive disorders, 12(3), 198–205. https://doi.org/10.1159/000051258.
Boller, F., Verny, M., Hugonot-Diener, L., & Saxton, J. (2002). Clinical features and assessment of severe dementia. A review. European journal of neurology, 9(2), 125–136. https://doi.org/10.1046/j.1468-1331.2002.00356.x.
Bonner, M. F., Ash, S., & Grossman, M. (2010). The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants. Current neurology and neuroscience reports, 10(6), 484–490. https://doi.org/10.1007/s11910-010-0140-4.
Braaten, A. J., Parsons, T. D., McCue, R., Sellers, A., & Burns, W. J. (2006). Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. The International journal of neuroscience, 116(11), 1271–1293. https://doi.org/10.1080/00207450600920928.
Cecchini, M. A., Yassuda,M. S., Bahia, V. S., de Souza, L. C., Guimaraes, H. C., Caramelli, P. et al. (2017). Recalling feature bindings differentiates Alzheimer’s disease from frontotemporal dementia. Journal of Neurology, 264(10), 2162–2169.
Charro-Gajate, C., Diéguez-Perdiguero, E., González-Fernández, J. y Goñi-Imízcoz, M. (2011), estudio comparativo de las características neuropsicológicas de la demencia por cuerpos de Lewy y de la enfermedad de Alzheimer, Psicogeriatría, 3 (2), 97-99.
Chételat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Ellis, K. A., Szoeke, C., Martins, R. N., O'Keefe, G. J., Salvado, O., Masters, C. L., Rowe, C. C., & Australian Imaging Biomarkers and Lifestyle Research Group (2010). Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Annals of neurology, 67(3), 317–324. https://doi.org/10.1002/ana.21955
Della Sala, S., Parra, M. A., Fabi, K., Luzzi, S., & Abrahams, S. (2012). Short-term memory binding is impaired in AD but not in non-AD dementias. Neuropsychologia, 50, 833–840.
Erkkinen, M. G., Kim, M. O., & Geschwind, M. D. (2018). Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harbor perspectives in biology, 10(4), a033118. https://doi.org/10.1101/cshperspect.a03311.
Galasko D. (2015). Expanding the Repertoire of Biomarkers for Alzheimer's Disease: Targeted and Non-targeted Approaches. Frontiers in neurology, 6, 256. https://doi.org/10.3389/fneur.2015.00256.
Groth-Marnat, G. (2009). Handbook of psychological assessment (5th ed.).
Hoboken, NJ: John Wiley & Sons.
Gurnani, A. S., & Gavett, B. E. (2017). The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis. Neuropsychology review, 27(1), 1–17. https://doi.org/10.1007/s11065-016-9334-0.
Harper, L., Bouwman, F., Burton, E. J., Barkhof, F., Scheltens, P., O'Brien, J. T., Fox, N. C., Ridgway, G., & Schott, J. M. (2017). Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis. Journal of Neurology, Neurosurgery and Psychiatry, 88(11), 908–916.
Harper L, Bouwman F, Burton EJ, et al. J Neurol Neurosurg Psychiatry 2017;88:908–916.
Hornberger, M., Piguet, O., Graham, A. J., Nestor, P. J., & Hodges, J. R. (2010). How preserved is episodic memory in behavioral variant frontotemporal dementia?. Neurology, 74(6), 472–479. https://doi.org/10.1212/WNL.0b013e3181cef85d
Hutchinson, A. D., & Mathias, J. L. (2007). Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review. Journal of neurology, neurosurgery, and psychiatry, 78(9), 917–928. https://doi.org/10.1136/jnnp.2006.100669
Iragorri Cucalón, Ángela María. (2007). Demencia frontotemporal. Revista Colombiana de Psiquiatría, 36(Suppl. 1), 139-156. Retrieved May 30, 2023, from http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74502007000500012&lng=en&tlng=es.
Irish, M., Piguet, O., Hodges, J. R., & Hornberger, M. (2014). Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and Alzheimer's disease. Human brain mapping, 35(4), 1422–1435. https://doi.org/10.1002/hbm.22263.
Josephs, K. A., Whitwell, J. L., Ahmed, Z., Shiung, M. M., Weigand, S. D., Knopman, D. S., Boeve, B. F., Parisi, J. E., Petersen, R. C., Dickson, D. W., & Jack, C. R., Jr (2008). Beta-amyloid burden is not associated with rates of brain atrophy. Annals of neurology, 63(2), 204–212. https://doi.org/10.1002/ana.21223.
Kawai, Y., Miura, R., Tsujimoto, M., Sakurai, T., Yamaoka, A., Takeda, A., Arahata, Y., Washimi, Y., Kachi, T., & Toba, K. (2013). Neuropsychological differentiation between Alzheimer's disease and dementia with Lewy bodies in a memory clinic. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 13(3), 157–163. https://doi.org/10.1111/psyg.12019.
Kozlova, I., Parra, M. A., Titova, N., Gantman, M., & Sala, S. D. (2021). Alzheimer's Disease and Parkinson Dementia Distinguished by Cognitive Marker. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 36(3), 307–315.
Mansoor, Y., Jastrzab, L., Dutt, S., Miller, B. L., Seeley, W. W., & Kramer, J. H. (2015). Memory profiles in pathology or biomarker confirmed Alzheimer disease and frontotemporal dementia. Alzheimer disease and associated disorders, 29(2), 135–140. https://doi.org/10.1097/WAD.0000000000000062.
Mavroudis, I. A., Petridis, F., Chatzikonstantinou, S., & Kazis, D. (2020). A meta-analysis on CSF neurogranin levels for the diagnosis of Alzheimer's disease and mild cognitive impairment. Aging clinical and experimental research, 32(9), 1639–1646. https://doi.org/10.1007/s40520-019-01326-z.
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., Aarsland, D., Arai, H., Ballard, C. G., Boeve, B., Burn, D. J., Costa, D., Del Ser, T., Dubois, B., Galasko, D., Gauthier, S., … Consortium on DLB (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology, 65(12), 1863–1872. https://doi.org/10.1212/01.wnl.0000187889.17253.b1.
Mummery, C. J., Patterson, K., Price, C. J., Ashburner, J., Frackowiak, R. S., & Hodges, J. R. (2000). A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. Annals of neurology, 47(1), 36–45.
Ng, A., Wang, J., Ng, K. K., Chong, J., Qian, X., Lim, J., Tan, Y. J., Yong, A., Chander, R. J., Hameed, S., Ting, S., Kandiah, N., & Zhou, J. H. (2021). Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia. Alzheimer's research & therapy, 13(1), 13. https://doi.org/10.1186/s13195-020-00752-w.
Otros biomarcadores asociados a la proteína Tau y daño neuronal, han sido estudiados extensivamente y en el año 2016 se incluyen en el sistema de clasificación ATN (Amyloid/Tau/Neurodegeneration) el cual congrega los 7 principales biomarcadores en la EA (Jack et al; 2016).
Rabinovici, G. D., Rosen, H. J., Alkalay, A., Kornak, J., Furst, A. J., Agarwal, N., Mormino, E. C., O'Neil, J. P., Janabi, M., Karydas, A., Growdon, M. E., Jang, J. Y., Huang, E. J., Dearmond, S. J., Trojanowski, J. Q., Grinberg, L. T., Gorno-Tempini, M. L., Seeley, W. W., Miller, B. L., & Jagust, W. J. (2011). Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology, 77(23), 2034–2042. https://doi.org/10.1212/WNL.0b013e31823b9c5e.
Ramanan, S., Bertoux, M., Flanagan, E., Irish, M., Piguet, O., Hodges, J. R., & Hornberger, M. (2017). Longitudinal Executive Function and Episodic Memory Profiles in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease. Journal of the International Neuropsychological Society : JINS, 23(1), 34–43. https://doi.org/10.1017/S1355617716000837.
Schubert, S., Leyton, C. E., Hodges, J. R., & Piguet, O. (2016). Longitudinal Memory Profiles in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 51(3), 775–782. https://doi.org/10.3233/JAD-150802.
Seeley, W.W., y Miller, B.L. (2018). Demencia frontotemporal. En J. Jameson, A.S. Fauci, D.L. Kasper, S.L.Hauser.
Shaik SS, Varma AR (2012) Differentiating the dementias: a neurological approach. Prog Neurol Psychiatry.
https://doi.org/10.1002/pnp.224
Tam, C. W., Burton, E. J., McKeith, I. G., Burn, D. J., & O'Brien, J. T. (2005). Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. Neurology, 64(5), 861–865. https://doi.org/10.1212/01.WNL.0000153070.82309.D4.
Whitwell, J. L., Jack, C. R., Jr, Parisi, J. E., Knopman, D. S., Boeve, B. F., Petersen, R. C., Ferman, T. J., Dickson, D. W., & Josephs, K. A. (2007). Rates of cerebral atrophy differ in different degenerative pathologies. Brain : a journal of neurology, 130(Pt 4), 1148–1158. https://doi.org/10.1093/brain/awm021.
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